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Table 1 Demographics and univariate analyses Group Number of patients Patient distribution (%) INR measurements per month % values in therapeutic range TTR Critical values per month All 4,326 100.0 2.809 83.9% 87.9% 0.085 Device used P= \0.0001 0.0113 0.0788 0.9746 CoaguChek XS 1,961 45.3 2.698 84.6% 88.5% 0.084 INRatio2 2,365 54.7 2.902 83.3% 87.4% 0.086 Gender P= \0.0001 \0.0001 \0.0001 0.0002 Male 2,925 67.6 2.707 84.5% 88.4% 0.070 Female 1,401 32.4 3.022 82.6% 86.7% 0.117 Age (years) P= 0.0001 0.1613 0.2454 0.0188 \45 363 8.4 2.849 82.9% 86.8% 0.096 45–64 2,000 46.2 2.759 84.1% 87.9% 0.088 65–74 1,363 31.5 2.773 84.4% 88.3% 0.071 75–79 311 7.2 2.805 84.2% 87.9% 0.087 80–84 182 4.2 3.217 82.2% 87.2% 0.123 C85 107 2.5 3.394 79.9% 85.0% 0.104 Indication P= 0.0564 0.0005 0.0139 0.0007 AF, no MHV 2,303 53.2 2.777 84.5% 88.3% 0.076 AF and MHV 47 1.1 2.878 78.8% 85.3% 0.136 MHV, no AF 297 6.9 2.857 84.1% 88.3% 0.088 DVT 728 16.8 2.750 84.4% 88.2% 0.084 Other 951 22.0 2.915 82.2% 86.6% 0.104 Therapeutic range P= 0.0001 0.0001 0.0001 0.0001 2.0–3.5 3,368 77.9 2.766 84.7% 88.6% 0.073 2.5–4.0 729 16.9 3.001 79.1% 84.4% 0.140 Others 229 5.3 2.842 87.4% 88.3% 0.092 Medication P= \0.0001 \0.0001 \0.0001 \0.0001 Acenocoumarol 3,359 77.6 2.831 82.9% 87.2% 0.087 Phenprocoumon 960 22.2 2.739 87.4% 90.0% 0.078 Others (warfarin) 7 0.2 Distribution of patients numbers, average INR measurements per month, share of measurements within therapeutic range, and TTR across devices used, gender, age, indication for anticoagulation, target therapeutic range, and medication used. Statistical significance of ANOVA for each group AF atrial fibrillation, DVT deep vein thrombosis, INR international normalized ratio, MHV mechanical heart valves, TTR time in therapeutic range, defined in this setting to include an additional 0.5 INR units (e.g. therapeutic range 2.0–3.5 for an international target range of 2.0–3.0) Adv Ther

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