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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
Research Phlebology In 1965 Mali and Kuiper described acro-angiodermatitis or pseudo Kaposi. From a pathogenic point of view, the authors describe pseudo Kaposi as a long-term complication of chronic venous insufficiency. Mali and Kuiper have studied pseudo Kaposi with mercury gauge plethysmography. Patients with pseudo Kaposi present an insufficiency not only of the muscular pump of the calf but also of the venous pump of the foot.[1] Kuiper and his colleagues studied venous insufficiency in dermatology.[2,3,4] Over the years they carried out assessments of the functioning of the venous system in parallel with clinical characterization of the signs and symptoms of venous insufficiency. Indirect venous resistance and capacity measurements were developed and standardized by the group. References 1. Mali JW, Kuiper JP, Hamers AA. Acro-angiodermatitis of the foot. Arch Dermatol. 1965; 92: 515-8. 2. Kuiper JP. Venous pressure determination (direct method). Dermatologica. 1966; 132: 206-17. 3. Brakkee AJ, Kuiper JP. [Indirect measurement of venous pressure in the lower limbs. Method, results and supplementary findings] (article in French) Phlebologie. 1978; 31(3): 237-48. 4. Brakkee AJ, Kuiper JP. Plethysmographic measurement of venous flow resistance in man. Vasa 1982; 11: 166-7. Genetics Happle had the vision that the distribution pattern of some skin disorders approaches the distribution of the lines as described by Blaschko. The typical dorsal V-shape and the abdominal S-figure of these lines are highly characteristic and not compatible with the distribution of dermatomes.[1] Blaschko’s lines represent a non-random developmental pattern of the skin. He described in several reports that these lines become manifest in the heterozygous state of various X-linked gene defects such as incontinentia pigmenti, focal dermal hypoplasia, X-linked dominant chondrodysplasia punctata, X-linked hypohidrotic ectodermal dysplasia, and Menkes syndrome. He hypothesised a causal relationship between lyonization and Blaschko’s lines, and suggested that in women affected with X-linked skin disorders, Blaschko’s lines visualize the clonal proliferation of two functionally different populations of cells during early embryogenesis of the skin. He described several new and existing skin conditions, arranged following the distribution pattern of Blaschko’s lines.[2,3] 99 Acro-angiodermatitis or pseudo-Kaposi of Mali. Lines of Blaschko in focal dermal hypoplasia. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 99