Please activate JavaScript!
Please install Adobe Flash Player, click here for download
ePaper created 2014-09-15, 12:31:02 | version 1.32.01
References 1. Berrens L. Studies with purified house dust allergen and observations on the nature of its polypeptide constituent. Clin Chim Acta 1963; 8: 457-65. 2. Berrens L, The allergens in house dust. Prog Allergy 1970; 14: 259-339. 3. Bleumink E, Berrens L: Synthetic Approaches to the Biological Activity of ?-Lactoglobulin in Human Allergy to Cows’ Milk (letter). Nature 1966; 212: 541-3. 4. Al-Ghouleh A, Johal R, Sharquie IK, et al. The glycosylation pattern of common allergens; the recognition and uptake of Der p1 by epithelial and dendritic cells is carbohydrate dependent . PloS One; 2012: 7(3):e33929. doi: 10. 1371/journal.pone.0033929. Epub 2012 Mar 30. Atopic dermatitis Research on atopic dermatitis has a longstanding tradition in Utrecht. In 1933 patients with eczema and prurigo were treated in an allergen-free room. Further, a special interest was taken in the cutaneous reactivity to human dander, since all atopic eczema patients showed positive immediate type skin responses to this product.[1] A breakthrough in the pathogenetic model of atopic dermatitis occurred in 1986 with the publication of a paper on the presence of IgE molecules on epidermal Langerhans cells in the lesional skin of patients with atopic dermatitis.[2] This linked the sensitization to allergens and the induction of eczema via allergen specific Th2 cells.[3] The induction of eczema by inhalant allergens, the atopy patch test, was internationally accepted as an in-vivo model for atopic dermatitis. In this model the phenotype of antigen specific T cells was studied, leading to the observation that, in the acute phase of eczema, the pattern was dominated by a Th2 type of inflammation and in the late or chronic phase by a Th1 type of inflammation.[4] The role of eosinophils and macrophages was also elucidated. In the meantime, clinical research was initiated to show the effect of house dust mite elimination on the clinical activity of eczema. This was carried out as a multicenter project in collaboration with the allergy departments of Rotterdam and Groningen.[5] Together with the department of pulmonary diseases, it could be shown that inhalation of allergens gave flare reactions especially in patients who also suffered from asthma.[6] 72 Atopic dermatitis. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 72