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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
cutaneous lymphomas. Clinical activities include weekly consultations for cutaneous lymphoma patients (headed by Maarten Vermeer) and weekly pathology panel meetings. Clinicopathologic correlation is essential in the diagnosis of cutaneous lymphomas and is guaranteed by the input of both a hematopathologist (Patty Jansen) and a dermatologist (Rein Willemze). Aided by the excellent research facilities in the LUMC, recent studies coordinated by Kees Tensen have focused on the molecular genetics of the different types of cutaneous lymphomas. Using micro-array based technology (gene expression profiling, comparative genomic hybridization, microRNA profiling) clear-cut differences in molecular alterations between different types of cutaneous lymphomas have been demonstrated and new diagnostic and prognostic markers identified.[8-10] These findings have resulted in functional studies on signalling pathways involved in the pathogenesis of some types of cutaneous lymphoma, which should contribute to novel therapeutic strategies. References 1. Vloten WA van, van Duijn P, Schaberg A. Cytodiagnostic use of Feulgen-DNA measurements in cell imprints from the skin of patients with mycosis fungoides. Brit J Dermatol 1974; 91: 365-71. 2. Meijer CJLM, van der Loo EM, van Vloten WA, et al. Early diagnosis of mycosis fungoides and Sézary syndrome by morphometric analysis of lymphoid cells in the skin. Cancer 1980; 45: 2864-71. 3. Willemze R, de Graaff-Reitsma CB, Cnossen J, et al. Characterization of T-cell subpopulations in skin and peripheral blood of patients with cutaneous T-cell lymphomas and benign inflammatory dermatoses. J Invest Dermatol 1983; 80: 60-6. 4. Willemze R, Kerl H, Sterry W, et al. EORTC classification for primary cutaneous lymp-ho-mas. Consensus report of the Cutaneous Lymp-homa Study Group of the Euro-pean Organization for Research and Treatment of Cancer (EORTC). Blood 1997; 90: 354-71. 5. Willemze R., Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-85. 6. Kim YH, Willemze R, Pimpinelli N, et al. TNM Classification System for Primary Cutaneous Lymphomas Other Than Mycosis Fungoides and Sézary Syndrome. A Proposal of the International Society for Cutaneous Lymphomas (ISCL) and The Cutaneous Lymphoma Study Group of the European Organization of Research and Treatment of Cancer (EORTC). Blood 2007; 110: 479-84. 7. Senff NJ, Noordijk EM, Kim YH, et al. European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood 2008; 112: 1600-9. 8. Hoefnagel JJ, Dijkman R, Basso K, et al. Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling. Blood 2005; 105: 3671-8. 9. Vermeer MH, van Doorn R, Dijkman R, et al. Novel and highly recurrent chromosomal alterations in Sézary syndrome. Cancer Res 2008; 68: 2689-98. 10. Kester MS van, Tensen CP, Vermeer MH, et al. Cutaneous Anaplastic Large Cell Lymphoma and Peripheral T-Cell Lymphoma NOS Show Distinct Chromosomal Alterations and Differential Expression of Chemokine Receptors and Apoptosis Regulators. J Invest Dermatol 2010; 130: 563-75. 87 BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 87