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References 1. Molhuizen, HO, Alkemade, HA, Zeeuwen, PL, et al. SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking. J Biol Chem 1993; 268: 12028-32. 2. Zeeuwen, PL, van Vlijmen-Willems, IM, Olthuis, D, et al. Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice. Hum Mol Genet 2004; 13: 1069-79. 3. Schalkwijk, J, Zweers, MC, Steijlen, PM, et al. A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency. N Engl J Med 2001; 345, 1167-75. 4. Zweers, MC, van Vlijmen-Willems, IM, van Kuppevelt, TH, et al. Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. J Invest Dermatol 2004; 122, 885-91. 5. Zeeuwen, PL, de Cid, R, Riveira-Munoz, E, et al. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. *shared first authorship. Nat Genet 2009; 41, 211-5. 6. Bergboer, JG, Tjabringa, GS, Kamsteeg, M, et al. Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups. Am J Pathol 2011; 178, 1470-7. 7. Bergboer, JG, Zeeuwen, PL, Irvine, AD, et al. Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. J Invest Dermatol 2010; 130, 2057-61. 8. Kamsteeg, M, Bergers, M, de Boer, R, et al. Type 2 helper T-cell cytokines induce morphologic and molecular characteristics of atopic dermatitis in human skin equivalent. Am J Pathol 2011; 178, 2091-9. 9. Tjabringa, G, Bergers, M, van Rens, D, et al. Development and validation of human psoriatic skin equivalents. Am J Pathol 2008; 173, 815-23. 10. Bogaard, EH van den, Bergboer, JG, Vonk-Bergers, M, et al. Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest 2013; 123: 917-27. Clinical dermatology In August 1960, an explosive epidemic of an erythema multiforme-like illness affected some tens of thousands of people after the introduction in the Netherlands of a margarine containing a new emulsifier. Mali and Malten described the clinical features of this illness and designated the disease as an ‘érythème du neuvième jour’. They showed antibodies against a by-product of the emulsifier ME-18.[1] Skin and mucosal diseases of the vulva represent an important challenge for the affected patients. At the Nijmegen Center, an interdisciplinary working group led by van der Vleuten and de Hullu was created to provide optimal care for women with vulvar diseases. Vulvar discomfort is a frequent problem in patients with inflammatory skin diseases. With respect to psoriasis it was shown that more than 30% of women had vulvar discomfort, which caused a substantial impairment to quality of life.[2] Malignancies of the vulva area are easily overlooked. The occurrence of malignancies in kidney transplant recipients was investigated at the Nijmegen center.[3-6] 105 BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 105