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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
Errol Prospero Prens At the laboratory of Immunology, Errol Prospero Prens (1956) developed with success the imiquimod mouse psoriasis model.[6] Since 2000 he and his co-investigators focused also on basic, translational and clinical aspects of hidradenitis suppurativa.[7] In 2000 the non-registered systemic therapy with fumarates was introduced by Thio for psoriasis vulgaris and since then, this therapy is considered a relevant option on the list of systemic therapies in psoriasis vulgaris.[8] In this modern era with several new biologics for the treatment of immune mediated inflammatory diseases (IMIDs), we started a cooperation with the Center for Human Drug Research in Leiden in order to expand our future possibilities of clinical research towards the early phase II studies. Regarding patient care within the university hospital, the interdisciplinary consultations in cooperation with the departments of Rheumatology and Clinical Immunology lifted up the quality of the care of IMID patients, for example those with psoriasis and arthritis. References 1. Naafs B, Kolk AH, Chin A Lien RA, et al. Anti-mycobacterium leprae monoclonal antibodies cross-react with human skin: an alternative explanation for the immune responses in leprosy. J Invest Dermatol 1990; 94: 685-8. 2. Engelkens HJ, Kate FJ ten, Vuzevski VD, et al. Primary and secondary syphilis: a histopathological study. Int J STD AIDS 1991; 2: 280-4. 3. Noordhoek GT, Engelkens HJ, Judanarso J, et al. Yaws in West Sumatra, Indonesia: clinical manifestations, serological findings and characterisation of new Treponema isolates by DNA probes. Eur J Clin Microbiol Infect Dis. 1991; 10: 12-9. 4. Joost T van, Heule F, Korstanje M, et al. Cyclosporin in atopic dermatitis: a multicenter placebo-controlled study. Br J Dermatol 1994; 130: 634-40. 5. O’Regan GM, Kemperman PM, Sandilands A, et al. Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes. J Allergy Clin Immunol 2010; 126: 574-80. 6. Fits L van der, Mourits S, Voerman JS, et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 2009; 182: 5836-45. 7. Zee HH van der, Ruiter L de, Broecke DG van der, et al. Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hydradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β. Br J Dermatol.2011; 164: 1292-8. 8. Fallah Arani S, Neumann H, Hop WC, et al. Fumarates vs. methotrexate in moderate to severe chronic plaque psoriasis: a multicenter prospective randomized controlled clinical trial. Br J Dermatol 2011; 164: 855-61. 133 BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 133