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References 1. Siemens HW. Dichtung und Wahrheit über die ‘Ichthyosis bullosa’mit Bemerkungen zür Systematik der Epidermolysen. Arch Dermatol Syphilol 1937; 175: 590-680. 2. Siemens HW. Die Technik der RechtsLinks-Behandlung für den Praktiker. Hautarzt 1952; 3: 307. 3. Polano MK. Topical Skin Therapeutics. Edinburgh: Churchill Livingstone, 1984. 4. Fitzpatrick TB, Polano MK, Suurmond D. Color atlas and Synopsis of clinical dermatology. New York: McGraw- Hill Book Co, 1983. Research Xanthomatosis, hyperlipoproteinaemia and atherosclerotic cardiovascular disease One of the fields of scientific research at the department of dermatology in Leiden was the study of the relationship between elevated blood lipids, xanthomatosis and atherosclerotic cardiovascular disease. These studies were initiated by Polano. He became interested in this topic during his dermatological training, when he examined a family in which xanthomatosis and early cardiac death occurred frequently. Probably this family suffered from familial hypercholesterolemia, a disease which was not yet described at that time. In 1964, after his appointment as head of the department, the Leiden Lipoproteinosis Working Group was founded, in which the departments of dermatology and metabolic diseases of the University Hospital cooperated with the Gaubius Institute of TNO (Netherlands Organisation for Applied Scientific Research).[1] In patients with different types of xanthomas the lipoprotein profiles were determined, seeking to establish a correlation between specific types of xanthomas and separate classes of lipoproteins.[2] It was found that in patients with tendon xanthomas the level of low density lipoproteins (LDL) was elevated, combined with normal levels of very low density lipoproteins (VLDL). In these patients the highest rate of cardiovascular disease was found. Tuberous xanthomas and papulo-eruptive xanthomas were found predominantly in patients with normal levels of LDL and ele- vated levels of VLDL. Patients with palmar xanthomas (xanthoma striata palmaris) were characterized by the presence of intermediate density lipoproteins.[3] These studies were continued by Vermeer. He investigated the relationship between xanthomatosis, atherosclerosis and hyperlipoproteinemia in biochemical and 84 Papulo-eruptive xanthomas. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 84