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References 1. Wingens, M, van Bergen, BH, Hiemstra, PS, et al. Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. J Invest Dermatol 1998; 111, 996-1002. 2. Hollox, EJ, Huffmeier, U, Zeeuwen, PL, et al. Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet 2008; 40, 23-5. 3. Jansen, PA, Rodijk-Olthuis, D, Hollox, EJ, et al. Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS One 2009; 4, e4725. 4. Jongh, GJ de, Zeeuwen, PL, Kucharekova, M, et al. High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol 2005; 125, 1163-73. 5. Koning, HD de, Kamsteeg, M, Rodijk-Olthuis, D, et al. Epidermal expression of host response genes upon skin barrier disruption in normal skin and uninvolved skin of psoriasis and atopic dermatitis patients. J Invest Dermatol 2011; 131, 263-6. 6. Zeeuwen, PL, Boekhorst, J, van den Bogaard, EH, et al. Microbiome dynamics of human epidermis following skin barrier disruption. Genome Biol 2012; 13, R101. 7. Bergboer JG, Oostveen AM, de Jager ME, et al. Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06. Br J Dermatol 2012; 167: 922-5. 8. Jager MEA de, Jong EMGJ de, Kerkhof PCM van de, Seyger MMB. Efficacy and safety of treatments for childhood psoriasis: A systematic literature review. JAAD 2010; 62, 1013–30 9. Körver JEM, Pasch MC, van Erp PEJ, et al. Assesment of epidermal subpopulations and proliferation in healty skin, symptomless and lesional skin of spreading psoriasis. Br J Dermatol 2006; 155: 688-945. 10. Vissers WH, Arndtz CH, Muys L, et al. Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late. Br J Dermatol. 2004; 150: 852-9. 109 Dermatology department staff, Nijmegen University Medical Center (1958). BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 109

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