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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
working group for the last 3 years. Multidisciplinary surgery of skin cancer at the Erasmus MC has developed in close collaboration with the plastic surgeons and the ocular surgeons. The histology is performed by dermatologist, supported by and in close collaboration with the department of pathology. An important issue in dermato-oncology at the Erasmus MC is the translational research performed in close collaboration with the Center of Optical Diagnostic and Therapy (CODT). The dermatology department has a key role in the research performed within the CODT. The use of Raman spectroscopy in the skin is being investigated. In addition to patient care a variety of research activities have been developed within the dermato-oncological domain. The use of photodynamic therapy (PDT) in dermatology was initiated in the early 1990’s.[4] The Rotterdam approach for light fractionated ALA-PDT is now applied as a standard treatment for PDT in pre-malignant conditions as actinic keratosis and superficial NMSC resulting in high long term clinical response rates.[5] Pre-clinical and clinical research is continued in a variety of aspects of PDT optical spectroscopy.[6] In addition to NMSC the research in PDT has now expanded in dermatology to anal intraepithelial neoplasia (AIN) and vulvar diseases such as vulvar intraepithelial neoplasia (VIN) and lichen sclerosus, using a variety of other esterified porphyrin pre-cursors like methyl-aminolaevulinate (MAL) and hexyl-aminolevulinate (HAL), nano-formulations of ALA and pre-formed chlorin photosensitisers.[7,8] References 1. Flohil SC, Vries E de, Neumann HA, et al. Incidence, prevalence and future trends of primary basal cell carcinoma in the Netherlands. Acta Derm Venereol 2011; 91: 24-30. 2. Vries E de, Micallef R, Brewster DH, et al. Population-based estimates of the occurrence of multiple vs first primary basal cell carcinomas in 4 European regions. Arch Dermatol 2012; 148: 347-54. 3. Flohil SC, Seubring I, Rossum MM van, et al. Trends in Basal cell carcinoma incidence rates: a 37-year Dutch observational study. J Invest Dermatol 2013; 133: 913-8. 4. Star WM, Veen AJ van ’t, Robinson DJ, et al. 5-Aminolaevulinic Acid Mediated Photodynamic Therapy of Superficial Basal Cell Carcinoma Using Two Light Fractions with a Two Hour Interval. Acta. Derm. Venereol 2006; 86: 412-7. 5. Vijlder HC de, Sterenborg HJCM, Neumann HAM, et al. Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolevulinic acid photodynamic therapy: five year follow up of a randomized prospective trial. Acta Dermatovenereol 2012; 92: 641-7. 136 Sclerosing basal cell carcinoma in the eyebrow, before (left) and after excision by Mohs micrographic surgery. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 136