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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
Paul Mier Mier showed that this mechanism is associated with the recruitment of cycling epidermal cells, which is the key process in psoriatic hyperproliferation of the epidermis.[9] Arachidonic acid release is controlled by phospholipase A2. The group of Mier has characterised this enzyme in psoriasis and showed that the enzyme activity is inc- reased in the unaffected skin of psoriatic patients.[10] References 1. Spruit D, Malten KE. Water vapour loss and skin barrier. An evaluation and some new findings. Trans St Johns Hosp Dermatol Soc 1971; 57: 167-76. 2. Malten KE, den Arend JA. Irritant contact dermatitis. Traumiterative and cumulative impairment by cosmetics, climate, and other daily loads. Derm Beruf Umwelt 1985; 33: 125-32. 3. Thiele FA, Malten KE. Insensible water loss. The inter-subject variation related to skin temperature, fore arm circumference and sweat gland activity. Trans St Johns Hosp Dermatol Soc 1972; 58: 199-217. 4. Reay DA, Thiele FA. Heat pipe theory applied to a biological system: quantification of the role of the “resting” eccrine sweat gland in thermoregulation. J Theor Biol 1977; 64: 789-803. 5. Erp PE van, De Mare S, Rijzewijk JJ, et al. A sequential double immunoenzymic staining procedure to obtain cell kinetic information in normal and hyperproliferative epidermis. Histochem J 1989; 21: 343-7. 6. Rijzewijk JJ, Van Erp PE, Bauer FW. Two binding sites for Ki67 related to quiescent and cycling cells in human epidermis. Acta Derm Venereol 1989; 69: 512-5. 7. Erp PE van, Rijzewijk JJ, Boezeman JB, et al. Flow cytometric analysis of epidermal subpopulations from normal and psoriatic skin using monoclonal antibodies against intermediate filaments. Am J Pathol 1989; 135: 865-70. 8. Erp PE van, Brons PP, Boezeman JB, et al. A rapid flow cytometric method for bivariate bromodeoxyu- ridine/DNA analysis using simultaneous proteolytic enzyme digestion and acid denaturation. Cytometry 1988; 9: 627-30. 9. Rijzewijk JJ, Bauer FW, Boezeman JB, et al. Recruitment of quiescent (G0) cells following epidermal injury is initiated by activation of the phosphoinositol cycle. J Invest Dermatol 1988; 90: 44-7. 10. Bergers M, Verhagen DR, Jongerius M, et al. A unique phospholipase A2 in human epidermis: its physiologic function and its level in certain dermatoses. J Invest Dermatol 1988; 90: 23-5. 103 BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 103