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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
Research Vasculitis allergica of Ruiter and Ruiter-Pompen-Weyers thesaurismosis lipoidica “His work was his life!” So says of Ruiter his friend and former colleague Henricus Martinus Maria Wentholt. “An outstanding and dedicated representative of dermatology; a scientist who also has great clinical skills”, so adds his pupil and later chef de clinique, Frans Henderikus Oswald. Both praise the man who played such a great role in the history of dermatology, and whose name became synonymous with the terms ‘vasculitis allergica’ or Gougerot-Ruiter disease, and with angiokeratoma corporis diffusum or Fabry’s disease, also called Ruiter-Pompen-Weyers thesaurismosis lipoidica. In Deventer in 1947 he wrote with colleagues internist Pompen and pathologist Weyers on angiokeratoma diffusum as a clinical marker for a phospholipid disease in the internal organs.[1] This publication helped him to be assigned in that same year as professor in Groningen. In 1952 he gained international recognition with the concept of vasculitis allergica.[2,3] Ruiter recognized that the disorder was an allergic reaction on various signals, such as bacteria, drugs, food additives, and insect bites. Only later it became apparent that the reaction was established by immunocomplex depositions. Normally, no treatment is necessary, and if the causing agent is identified and eliminated the symptoms largely vanish quickly. At the end of his ordinariate he was the first to use the electron microscope in collaboration with his co-worker and biologist Dr. Van Mullem. They demonstrated the human papilloma virus as cause of epidermodysplasia verruciformis, and revealed lipid inclusions in endothelial cells in angiokeratoma corporis diffusum.[4,5] References 1. Pompen AW, Ruiter M, Weyers HJ. Angiokeratoma corporis diffusum (universale) Fabry, as a sign of an unknown internal disease; two autopsy reports. Acta Med Scand. 1947; 128: 234-55. 2. Ruiter M. Allergic cutaneous vasculitis. Acta Derm Venereol. 1952; 32: 274-88. 3. Ruiter M. Vascular fibrinoid in cutaneous allergic arteriolitis. J Invest Dermatol. 1962; 38: 85-92. 4. Ruiter M, van Mullem PJ. Demonstration by electronmicroscopy of an intranuclear virus in epidermodysplasia verruciformis. J Invest Dermatol 1966; 47: 247-52. 5. Mullem PJ van, Ruiter M. Electron-microscopical investigation of the skin in angiokeratoma corporis diffusum. Dermatologica 1968; 136: 281-2. 53 Vasculitis allergica. Skin biopsy in Fabry’s disease with vacuolization of endothelial cells. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 53