Please activate JavaScript!
Please install Adobe Flash Player, click here for download
ePaper created 2014-09-15, 12:31:02 | version 1.32.01
References 1. Rooij MJ de, Rampen FH, Schouten LJ, et al. Skin cancer screening focusing on melanoma yields more selective attendance. Arch Dermatol 1995; 131: 422-5. 2. Tilli CM, Van Steensel MA, Krekels GA, et al. Molecular aetiology and pathogenesis of basal cell carcinoma. Review. Br J Dermatol 2005; 152: 1108-24. 3. Brinkhuizen T, van den Hurk K, Winnepenninckx VJ, et al. Epigenetic changes in Basal Cell Carcinoma affect SHH and WNT signaling components. PLoS One 2012; 7:e51710. 4. Ostertag JU, Quaedvlieg PJ, Kerckhoffs FE, et al. Congenital naevi treated with erbium:YAG laser (Derma K) resurfacing in neonates: clinical results and review of the literature. Br J Dermatol 2006; 154: 889-95. 5. Quaedvlieg PJ, Creytens DH, Epping GG, et al. Histopathological characteristics of metastasizing squamous cell carcinoma of the skin and lips. Histopathology 2006; 49: 256-64. 6. Smeets NW, Krekels GA, Ostertag JU, et al. Surgical excision vs Mohs micrographic surgery for basal-cell carcinoma of the face: randomised controlled trial. Lancet 2004; 364: 1766-72. 7. Mosterd K, Krekels GA, Nieman FH, et al. Surgical excision versus Mohs micrographic surgery for primary and recurrent basal-cell carcinoma of the face: a prospective randomised controlled trial with 5-years’ follow-up. Lancet Oncol 2008; 9: 1149-56. 8. Thissen MR, Schroeter CA, Neumann HA. Photodynamic therapy with delta-aminolaevulinic acid for nodular basal cell carcinomas using a prior debulking technique. Br J Dermatol 2000; 142: 338-9. 9. Roozeboom MH, Aardoom MA, Nelemans PJ, et al. Fractionated 5-aminolevulinic acid photodynamic therapy after partial debulking versus surgical excision for nodular basal cell carcinoma: A randomized controlled trial with at least 5-year follow-up. J Am Acad Dermatol 2013; 69: 280-7. 10. Arits AH, Mosterd K, Essers BA, et al. Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. Lancet Oncol 2013; 14: 647-54. Phlebology In 1992 Neumann started phlebology patient care and research. In the beginning only conventional therapy, such as compression therapy, was used in daily practice and also subject of research.[1] However, soon the so called Muller ambulatory phlebectomy was started, a minimal invasive technique for removing varicose veins under local anesthesia. Neumann had mastered this technique in Switzerland in the clinic of the famous doctor Muller himself. In a randomized trial the superiority of Muller’s phlebectomy over compression sclerotherapy could later on be proven.[2] In 1996 the outpatient clinic was equipped with a duplex ultrasound, so the dermatologists could perform their own vascular investigation. Duplex is much more reliable in the diagnosis of (incompetent) veins that the previous used Doppler. Now vascular vessels could become visible and tested on their functionality. Besides introduction of these new procedures for daily practice, cooperation was implemented with the Cardiovascular research group of the University of Maastricht (CARIM), for more fundamental research. The intention was to focus on the microcirculation in chronic venous insufficiency and post thrombotic syndrome. It was found that Factor V Leiden mutation is more frequent present in 148 BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:41 Pagina 148