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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
6. Middelburg TA, Kanick SC, Haas ERM de, et al. Monitoring blood volume and saturation using superficial fibre optic reflectance spectroscopy during PDT of actinic keratosis. Journal of Biophotonics 2011; 10: 721-30. 7. Snoek EM van der, Hollander JC den, Aans JB, et al. Photodynamic therapy with systemic meta-tetrahydroxy- phenylchlorin in the treatment of anal intraepithelial neoplasia grade 3. Lasers Surg Med 2012; 44: 637-44. 8. Bruijn HS de, Haas ER de, Hebeda KM, et al. Light fractionation does not enhance the efficacy of methyl 5-aminolevulinate mediated photodynamic therapy in normal mouse skin. Photochem Photobiol Sci 2007; 6: 1325-31. Dermato-epidemiology The objective of most epidemiologic research is to measure the frequency of disease occurrence (and its trend in time) and/or to obtain a valid and precise estimate of the effect of a potential cause on the occurrence of disease (i.e., identification of risk factors). In addition, epidemiology is the methodological backbone for fields of public health, evidence-based medicine, and outcome research. Fundamentally, epidemiologic studies put the individual’s condition in a population context. Tamar Edmond Christoffel Nijsten The departments of Epidemiology and Public Health of the Erasmus MC have an outstanding scientific reputation and form the back bone of the Netherlands Institute of Health Sciences (NIHES). From 2005 onwards, the relationship between these departments and the epidemiology division of the dermatology department, headed by Tamar Edmond Christoffel Nijsten (1972; photograph on page 5), intensified. Initially, collaborative projects on the epidemiology of skin cancer were started using the unique Dutch population based cancer registries that include basal cell carcinoma (BCC). In multiple studies, we showed the continuous increase of the incidence over time of BCC, squamous cell carcinoma and melanoma.[1,2] Also, the national pathology database was used for a more detailed analysis allowing us to demonstrate that approximately 30% of the people with a first BCC develop more BCC’s within 5 years.[3] In addition to assess incidences and trends over time, a focus was put on gender differences in melanoma survival showing that female melanoma patients are significantly more likely to survive melanoma, independent of all known risk factors and in three of the four tumour stages. Also, we demonstrated that skin cancer is considered as a chronic disease, since patients often suffer from multiple skin cancers, it impairs their health related quality of life, and that impairment and burden of disease analyses show that people live many years with their diagnosis.[4-6] This line of research was expanded tot pharmaco- epidemiological studies by linking pharmacy database (PHARMO RLS) to pathology databases and later on to one of the four cancer registries.[7] One of the objectives was to investigate 137 Multiple basal cell carcinomas on the left cheek. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 137