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References 1. Tjiam KH, van Eijk RV, van Heijst BY, et al. Evaluation of the direct fluorescent antibody test for diagnosis of chlamydia infections. Eur J Clin Microbiol. 1985; 4: 548-52. 2. Sluis JJ van der, Menke HE. Role of IgG fractions with high isoelectric points in the thymol turbidity test in syphilis. Evidence for an increase in basic IgG in early syphilis. Br J Vener Dis 1975; 51: 158-60. 3. Engelkens HJ, Judanarso J, Sluis JJ van der, et al. Disseminated early yaws: report of a child with a remarkable genital lesion mimicking venereal syphilis. Pediatr Dermatol 1990; 7: 60-2. 4. Schee C van der, Belkum A van, Zwijgers L, et al. Improved diagnosis of Trichomonas vaginalis infection by PCR using vaginal swabs and urine specimens compared to diagnosis by wet mount microscopy, culture, and fluorescent staining. J Clin Microbiol 1999; 37: 4127-30. 5. Snoek EM van der, Niesters HG, Mulder PG, et al. Human papillomavirus infection in men who have sex with men participating in a Dutch gay-cohort study. Sex Transm Dis 2003; 30: 639-44. 6. Snoek EM van der, de Wit JB, Mulder PG, et al. Incidence of sexually transmitted diseases and HIV infection related to perceived HIV/AIDS threat since HAART availability in men who have sex with men. Sex Transm Dis 2005; 32: 170-5. 7. Nieuwenhuis RF, Ossewaarde JM, Götz HM, et al. Resurgence of lymphogranuloma venereum in Western Europe: an outbreak of Chlamydia trachomatis serovar L2 proctitis in The Netherlands among men who have sex with men. Clin Infect Dis 2004; 39: 996-1003. 8. Nieuwenhuis RF, Ossewaarde JM, Meijden WI van der, et al. Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin. Sex Transm Infect 2003; 79: 453-5. 9. Snoek EM van der, Ossewaarde JM, van der Meijden WI, et al. The use of serological titres of IgA and IgG in (early) discrimination between rectal infection with non-lymphogranuloma venereum and lymphogranuloma venereum serovars of Chlamydia trachomatis. Sex Transm Infect 2007; 83: 330-4. 10. Lanjouw E, Ossewaarde JM, Stary A, et al. 2010 European guideline for the management of Chlamydia trachomatis infections. Int J STD AIDS 2010; 21: 729-37. Immunology & inflammation In the early years basic and clinical research were focused on tropical infections and sexually transmitted diseases.[1,2] Stolz accommodated research in this field in cooperation with international partners such as the Department of Dermatology and Venereology, Cipto Mangunkusomo Hospital, University of Indonesia, Jakarta. The inflammatory aspects of these infections were of great interest.[3] With the introduction of cyclosporin in the late 1980’s the Department of Dermatology put more effort in the research of atopic dermatitis and type IV skin allergies.[4] Paediatric dermatology gained more and more attention. In the field of atopy / atopic dermatitis, Raman spectroscopy proved to be a high-tech methodological instrument to analyse the role of filaggrin (filament - aggregating protein).[5] This protein plays a key role in epidermal barrier function. The gene FLG is encoded within the epidermal differentiation complex on chromosome 1q21, a cluster of genes involved in the terminal differentiation of keratinocytes in the skin. 132 BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 132