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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
Leendert Hendrikus Jansen Zoon’s successor, Leendert Hendrikus Jansen (1916-1977), presided over a busy period of scientific development and expansion of the Utrecht Dermatology Institute. Unlike his predecessor, Jansen preferred to give his staff more free rein. In 1955, Jansen described the abnormal structure of the dermal collagen fibers in Ehlers-Danlos syndrome.[2] Along with his Utrecht colleague, Jan B. van der Meer, who published on dermatitis herpetiformis, Jansen was the only other Dutch dermatologist who was included in the Citation Classics from dermatological journals between 1945 and 1990. Cormane was the first to describe bound globulin in the skin of patients with chronic discoid lupus erythematosus (CDLE) and systemic lupus erythematosus (SLE). This method was also useful for cases in which the clinical and histolo- gical diagnoses were questionable.[3,4] In those days, immunofluorescence studies were popular in Utrecht. In 1969 van der Meer used direct immunofluorescence to describe granular deposits of IgA in the dermal papillae of perilesional and uninvolved skin in dermatitis herpetiformis.[5] In 1973 Eva Baart de la Faille-Kuyper et al. demonstrated that there were IgA deposits not only in renal glomeruli but also in skin vessels in patients with Henoch-Schönlein vasculitis.[6] 66 Clinical picture of dermatitis herpetiformis on the knee. Granular IgA in the papillary dermis in dermatitis herpetiformis. Dermatitis herpetiformis with infiltrate of mainly neutrophils in the papillary dermis. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 66