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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
References 1. Rossum MM van, Wopereis D, Hoyer T, et al. Incidence of cancer in first-degree relatives of basal cell carcinoma patients. Arch Dermatol Res 2009; 301: 295-9. 2. Stacey SN, Sulem P, Masson G, et al. New common variants affecting susceptibility to basal cell carcinoma. Nat Genet 2009; 41: 909-14. doi: 10. 1038/ng.412. Epub 2009 Jul 5. 3. Stacey SN, Sulem P, Jonasdottir A, et al. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nat Genet 2011; 43: 1098-103. doi: 10. 1038/ng.926. 4. Szeimies RM, Gerritsen MJ, Gupta G, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol 2004; 51: 547-55. 5. Kleinpenning MM, van de Kerkhof PC, Gerritsen RM. The clinical efficacy of topical methyl-aminolevulinate photodynamic therapy in moderate to severe actinic keratoses of the face and scalp. J Dermatolog Treat 2010; 21: 252-7. 6. Wiegell SR, Wulf HC, Szeimies RM, et al. Daylight photodynamic therapy for actinic keratosis: an international consensus: International Society for Photodynamic Therapy in Dermatology. J Eur Acad Dermatol Venereol 2012; 26: 673-9. 7. Basset-Seguin N, Baumann Conzett K, Gerritsen MJ, et al. Photodynamic therapy for actinic keratosis in organ transplant patients. J Eur Acad Dermatol Venereol 2013; 27: 57-66. Pathogenesis of psoriasis In the late nineties we were one of the first laboratories in dermatology to apply transcriptomics technology (microarrays and SAGE). From these studies we identified a number of new genes that were involved in skin biology.[1] We shifted our interest to the genetics of disease. We demonstrated that the epidermis-expressed beta-defensin cluster on chromosome 8 was subject to a copy number polymorphism that is associated with psoriasis This seminal finding was published in Nature Genetics.[2] We showed that the potent antimicrobial protein beta-defensin-2 is highly inducible in human skin, and is expressed at biologically relevant levels.[3] Expression of antimicrobial proteins is different between psoriasis and atopic dermatitis.[4] Recently we have turned our attention to pattern recognition receptors in skin, and reported on the expression of these molecules in human epidermis.[5] We were the first group to report the dynamics of the skin microflora (the ‘microbiome’) and show sex differences.[6] 107 Plaque type psoriasis. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 107