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ePaper created 2014-09-15, 12:31:02 | version 1.32.01
syndrome, including a strong association with pancreatic cancer.[3] The Leiden melanoma group plays a key role in the International Melanoma Genetics Consortium (GenoMEL; www.genomel.org), which was founded in 1997, and was formalized as an EU network of excellence in 2005. This group, of which Nelleke Gruis is also vice-coordinator, participates in many collaborative projects on penetrance, susceptibility and modifying genes and gene-environment interactions in melanoma.[4,5] Recent studies of the Leiden group focused on (epi)genetic alterations that drive the subsequent stages of melanoma progression, and on optimal screening and management of familial melanoma patients.[6-9] Besides research, the department has a longstanding tradition in postgraduate education. Recently a series of courses on dermoscopy was awarded the Boerhaave Penning for teaching excellence. The course was considered an outstanding example of blended learning aimed both at general practitioners and advanced dermoscopists. To underline the aspirations of the department in early diagnosis and prevention of melanoma, Wilma Bergman was appointed teaching professor by the Melanoma Patient Society in 2008. The efforts of our melanoma group will certainly continue to revolve around these themes in the years to come. References 1. Bergman W, Palan A, Went LN. Clinical and genetic studies in six Dutch kindreds with Dysplastic Nevus Syndrome. Ann Hum Genet 1986; 50: 249-258. 2. Gruis NA, van der Velden PA, Sandkuijl LA, et al. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds. Nat Genet 1995; 10: 351-3. 3. Snoo FA de, Bishop DT, Bergman W, et al. Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families. Clin Cancer Res. 2008; 14: 7151-7. 4. GenoMEL Consortium. Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet 2011; 43: 1108-13. 89 LUMC Melanoma Group. From left to right: Remco van Doorn, Nicole Kukutsch, Nelleke Gruis, Wilma Bergman. BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 89