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References 1. Mali JW, Malten KE. The epidemic of polymorph toxic erythema in the Netherlands in 1960. The so-called margarine disease. Acta Derm Venereol 1966; 46: 123-35. 2. Meeuwis KA, de Hullu JA, de Jager ME, et al. Genital psoriasis: a questionnaire-based survey on a concealed skin disease in the Netherlands. J Eur Acad Dermatol Venereol 2010; 24: 1425-30. doi: 10. 1111/j. 1468- 3083.2010.03663.x. 3. Meeuwis KA, van Rossum MM, Hoitsma AJ, et al. (Pre)malignancies of the female anogenital tract in renal transplant recipients. Transplantation 2011; 91: 8-10. 4. Meeuwis KA, de Hullu JA, van de Nieuwenhof HP, et al. HPV-related (pre)malignancies of the male anogenital tract in renal transplant recipients. Quality of life and sexual health in patients with genital psoriasis. Br J Dermatol 2011; 164: 1247-55. doi: 10. 1111/j. 1365-2133.2011. 10249.x. Epub 2011 May 13. 5. Hinten F, Meeuwis KA, van Rossum MM, et al. HPV-related (pre)malignancies of the female anogenital tract in renal transplant recipients. Crit Rev Oncol Hematol 2012; 84: 161-80. 6. Meeuwis KA, Melchers WJ, Bouten H, et al. Anogenital malignancies in women after renal transplantation over 40 years in a single center. Transplantation 2012; 93: 914-22. Oncology There is evidence to suggest that genetic factors play an important role in the development of basal cell carcinomas (BCCs), and that skin neoplasms might be a sign for a genetic predisposition to cancer. We investigated whether the incidence of visceral and skin malignancies among first-degree relatives of BCC patients was increased. The incidence of the following cancers was higher than expected in relatives from young BCC patients: bone and soft tissue, skin and digestive tract. In relatives of older BCC patients, only the incidence of digestive tract cancer was higher than expected. This study suggests that the risk of certain cancers, particularly that of the digestive tract, in first-degree relatives of BCC patients is increased. These findings may indicate a genetic predisposition to both skin and visceral malignancies in this patient group.[1-3] Various new approaches in the treatment of actinic keratosis have been introduced. At the Nijmegen Center the focus of research has been on the treatment of multiple actinic keratosis, non-melanoma skin cancer and field cancerisation. Multi-center studies revealed that imiquimod is effective in the treatment of actinic keratosis.[4] A study in the Nijmegen department showed that topical methyl- aminolevulinate photodynamic therapy is effective in moderate to severe actinic keratoses of the face and scalp.[5] Photodynamic therapy is indicated in particular for the treatment of field cancerisation.[6,7] 106 BWEADVSMGFINCORR:Opmaak 1 21-07-2014 17:40 Pagina 106